Fenofibrate

isopropyl [4prime-( p- chlorobenzoyl)-2-phenoxy-2-methyl]propionate; procetofen; procetofene

Ankebin (Volpino) ; Elasterin (Phoenix) ; Fenobrate (Gramon) ; Feno tard (Virbac) ; Lipanthyl (Fournier) ; Lipantil (Fournier) ; Lipidil (Ibirn) ; Lipoclar (Crinos) ; Lipo fene (Teofarma) ; Liposit (SIT) ; Lipsin (Fournier) ; Nolipax (Foscama) ; Procetoken (Bernabo) ; Protolipan (Millet) ; Secalip (Fournier) ; Tricor (Abbott)

360.84

C 66.57%, H 5.87%, Cl 9.83%, O 17.74%

Prepn: A. Mieville, Ger. pat. 2,250,327 (1973 to Orchimed), C.A. 79, 53029 (1973), addn to Ger. pat. 2,003,430; eidem, U.S. pat. 4,058,552 (1970, 1977 both to Orchi med). Series of articles on synthesis, metabo lism, pharmacology and clinical trials: Arzneimittel-Forsch. 26, 885-909 (1976). Toxicity data: R. Sornay et al., ibid. 885. GC-MS of major metabolite in humans: L. F. Elsom et al., J. Chrom atog. 123, 463 (1976). Efficacy in hyperlipid emias: H. B. Staumlhe lin et al., Praxis 68, 24 (1979). Effect on human biliary lipids: E. M. Grandjean et al., Schweiz. Med. Wo chen schr. 109, 601 (1979). Mechanism of action: W. Wül fert et al., Artery 9, 120 (1981).

Crystals from isopropanol, mp 80-81degrees . Practically insol in water. Slightly sol in methanol, ethanol. Sol in acetone, ether, benzene, chloroform. LD 50 in mice: 1600 mg/kg orally (Sornay)