Fluticasone Propionate
Manufacturer & Exporter of Fluticasone PropionateMonograph number:
4244
Title
Fluticasone Propionate
Specification
BP/EP/USP
Category
Antiallergic (Anti-inflammatory) Cortico Steroid
DMF Status
TP (Technical Package)
CAS Registry number
[80474-14- ]
CAS name(s)
(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S -(fluoromethyl) ester
Additional name(s)
S - fluoromethyl 6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-17alpha-propionyloxy-3-oxoandrosta-1,4-diene-17beta-carbothio ate
Trade name(s)
Cutivate (Glaxo Wellcome) ; Flixonase (Allen and Hanburys) ; Flixotide (Allen and Hanburys) ; Flonase (Glaxo Wellcome) ; Flovent (Glaxo Wellcome) ; Flunase (Glaxo Wellcome)
Drug code(s)
CCI-18781
Molecular formula
C 63 H 91 CoN 13 O 14 P
Molecular weight
500.58
Percent Composition
C 59.99%, H 6.24%, F 11.39%, O 15.98%, S 6.41%
.
Literature references
Derivative of flumethasone, q.v. Prepn: Neth. pat. Appl. 81 00,707; G. H. Phillipps et al., U.S. pat. 4,335,121 (1981, 1982 both to Glaxo). Series of articles on structure-activity, pharmacology and clinical studies: Respir. Med. 84, Suppl. A, 19-35 (1990). Clinical trials in allergic rhinitis: E. O. Meltzer et al., J. Allergy Clin. Immunol. 86, 221 (1990). Evaluation in untreated celiac disease: H. C. Mitchison et al., Gut 32, 260 (1991)
Properties
Crystals, mp 272-273degrees (dec) . [alpha] D +30degrees (c = 0.35) . Practically insol in water. Freely sol in DMSO, DMF; slightly sol in methanol, 95% ethanol
Melting Point
272-273degrees Rotation: +30
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